After ROSC, what is the recommended FiO₂ titration goal for a patient's SpO₂?

The recommended target for titrating fractional inspired oxygen (FiO₂) after Return of Spontaneous Circulation (ROSC) is to achieve an oxygen saturation (SpO₂) of 94-99%. This range is considered optimal because maintaining SpO₂ within these parameters ensures adequate oxygen delivery to tissues without the risks associated with hyperoxia, such as oxidative stress and potential injury to the lungs and other organs.

While aiming for 100% oxygen may seem ideal for maximizing oxygen availability, it can lead to complications, including decreased lung compliance and potential rebound hypoxia upon weaning. Targeting a saturation of 88-92% does not provide sufficient oxygenation for most patients, especially following a cardiac arrest event. Additionally, maintaining an SpO₂ of 90-94% does not fully capitalize on the benefits of a higher range necessary for effective organ perfusion and recovery.

Therefore, maintaining an SpO₂ within the 94-99% range post-ROSC is crucial for patient stabilization and optimal outcomes, aligning with current guidelines for post-resuscitation care.